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KMID : 0363220140520040244
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Korean Journal of Dermatology
2014 Volume.52 No. 4 p.244 ~ p.251
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Comparison of Wound Repair after Irradiation of Rat Skin with 1064 nm Nd:YAG, CO2, and Er:YAG Lasers
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Kim Hyun-Jo
Lee Gang-Mo
Park Young-Lip
Lee Jong-Suk
Whang Kyu-Uang
Lee Sung-Yul
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Abstract
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Background: Laser therapy for various skin conditions is one of the most common procedures in dermatology. Recently, several articles described the use of 1064 nm Q-switched Nd:YAG lasers for the treatment of benign skinlesions. Such treatment is known to trigger its therapeutic effect through a photoacoustic effect and selectivephotothermolysis effect. However, only a limited number of articles have dealt with the theoretical base of thephotoacoustic effect of the 1064 nm Q-switched Nd:YAG laser.
Objective: To compare the wound repair process and nonselective tissue heat damage induced by three differentlaser modalities: the CO2 laser, Er:YAG laser, and 1064 nm Q-switched Nd:YAG laser.
Methods: We irradiated the skin of an albino rat (Sprague Dawleyⓡ, 200∼250 g) with CO2, Er:YAG, and 1064nm Q-switched Nd:YAG lasers. Skin biopsy specimens of the irradiated areas were collected on the first, fifth, andtenth day after laser exposure. For histologic analysis, the specimens were stained with the H&E, Verhoff-VanGieson, and Masson’s trichrome protocols. Results: Compared with other laser modalities, rat skin irradiated by the 1064 nm Q-switched Nd:YAG lasershowed the least amount of heat damage and the quickest tissue repair response to the damage.
Conclusion: A 1064 nm Q-switched Nd:YAG laser with a photoacoustic effect capable of ablating the epidermisand dermis can be a proper treatment modality for the removal of benign skin lesions. The 1064 nm Q-switchedNd:YAG laser may be considered as an alternative treatment option for the treatment of benign skin lesions.
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KEYWORD
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1064 nm Q-switched Nd, YAG Laser, CO2 Laser, Er:YAG Laser, Wound repair, Non selective tissue heat damage, Sprague Dawleyⓡ
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